PrimePCR™ Probe Assay: ATF1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: ATF1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: ATF1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0027267
Assay Design:   Intron-spanning
Chromosome Location:   12:51203303-51207852question
Amplicon Length:   100
Splice Variants Targeted:   ENST00000552510 ENST00000262053 ENST00000552487

Gene Information

This gene encodes an activating transcription factor which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes which are related to growth survival and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases cAMP-dependent protein kinase A calmodulin-dependent protein kinase I/II mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq Aug 2010]

Gene Symbol:   ATF1
Gene Name:   activating transcription factor 1
Aliases:   EWS-ATF1, FUS/ATF-1, TREB36
RefSeq:   NC_000012.11 NG_027673.1 NT_029419.12
Ensembl:   ENSG00000123268
Entrez:   466
Chromosome Mapping:   12q13

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