PrimePCR™ Probe Assay: JAM3, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0040491
Assay Design:   Intron-spanning
Chromosome Location:   11:134014809-134015862question
Amplicon Length:   73
Splice Variants Targeted:   ENST00000299106 ENST00000441717 ENST00000529443

Gene Information

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain subependymal calcification and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq Apr 2011]

Gene Symbol:   JAM3
Gene Name:   junctional adhesion molecule 3
Aliases:   FLJ14529, JAM-C, JAMC
RefSeq:   NC_000011.9 NT_033899.8
Ensembl:   ENSG00000166086
Entrez:   83700
Chromosome Mapping:   11q25

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