PrimePCR™ Probe Assay: TAP2, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: TAP2, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: TAP2, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0040018
Assay Design:   exonic
Chromosome Location:   6:32793950-32794044question
Amplicon Length:   65
Splice Variants Targeted:   ENST00000455842 ENST00000452371 ENST00000419142 ENST00000443713 ENST00000383239 ENST00000383118 ENST00000457634 ENST00000374897

Gene Information

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1 MDR/TAP MRP ALD OABP GCN20 White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis insulin-dependent diabetes mellitus and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq Jul 2008]

Gene Symbol:   TAP2
Gene Name:   transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Aliases:   ABC18, ABCB3, APT2, D6S217E, PSF2, RING11
RefSeq:   NC_000006.11 NG_028165.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1 NT_167249.1 NG_009793.1 NG_012008.1
Ensembl:   ENSG00000204267
Entrez:   6891
Chromosome Mapping:   6p21.3

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