Gene:  MKNK2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Design and Validation of Real-Time PCR Primers-test
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Control and Reference Assays for Real-Time PCR

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E) thus playing important roles in the initiation of mRNA translation oncogenic transformation and malignant cell proliferation. In addition to eIF4E this protein also interacts with von Hippel-Lindau tumor suppressor (VHL) ring-box 1 (Rbx1) and Cullin2 (Cul2) which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation and in subcellular localization. [provided by RefSeq Aug 2011]

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My PrimePCR Hot List stores your saved PrimePCR products and configurations

My PrimePCR Hot List stores your saved PrimePCR products and configurations

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My PrimePCR Hot List stores your saved PrimePCR products and configurations

My PrimePCR Hot List stores your saved PrimePCR products and configurations

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