Beta-2 adrenergic-dependent CFTR expression

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Beta-2 Adrenergic Dependent CFTR H96

Predesigned 96-well panel for use with SYBR® Green

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Beta-2 Adrenergic Dependent CFTR H384

Predesigned 384-well panel for use with SYBR® Green

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Beta-adrenergic-dependent CFTR expression

Beta-adrenergic receptor modulates expression of the Cystic fibrosis transmembrane conductance regulator (CFTR) [1] via elevation of Adenosine 3',5'-cyclic phosphate -(cAMP) mediated by GNAS complex locus (G-protein alpha-s)/ Adenylate cyclase/ cAMP. High cAMP concentration leads to activation of the PKA and, subsequently, of cAMP responsive element binding protein 1 (CREB1) and transcription factor 1 (ATF-1)-dependent transcription of CFTR. cAMP-dependent activation of CFTR transcription is still being studied and appears to be more complex than believed previously [1], [2], [3].

References:

Matthews RP, McKnight GS
Characterization of the cAMP response element of the cystic fibrosis transmembrane conductance regulator gene promoter. The Journal of biological chemistry 1996 Dec 13;271(50):31869-77
Pittman N, Shue G, LeLeiko NS, Walsh MJ
Transcription of cystic fibrosis transmembrane conductance regulator requires a CCAAT-like element for both basal and cAMP-mediated regulation. The Journal of biological chemistry 1995 Dec 1;270(48):28848-57
McDonald RA, Matthews RP, Idzerda RL, McKnight GS
Basal expression of the cystic fibrosis transmembrane conductance regulator gene is dependent on protein kinase A activity. Proceedings of the National Academy of Sciences of the United States of America 1995 Aug 1;92(16):7560-4

GeneCode	Beta-2 Adrenergic Dependent CFTR M96	Beta-2 Adrenergic Dependent CFTR M384
Adcy3	✓	✓
Adrb1	✓	✓
Adrb2	✓	✓
Adrb3	✓	✓
Cftr	✓	✓
Creb1	✓	✓
Gapdh	✓	✓
Hprt	✓	✓
Prkacb	✓	✓
Prkar1a	✓	✓
Tbp	✓	✓

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GeneCode	Beta-2 Adrenergic Dependent CFTR H96	Beta-2 Adrenergic Dependent CFTR H384
ADCY1	✓	✓
ADCY2	✓	✓
ADCY3	✓	✓
ADCY5	✓	✓
ADRB1	✓	✓
ADRB2	✓	✓
ADRB3	✓	✓
ATF1	✓	✓
CFTR	✓	✓
CREB1	✓	✓
GAPDH	✓	✓
GNAS	✓	✓
HPRT1	✓	✓
PRKACB	✓	✓
PRKAR1A	✓	✓
PRKAR1B	✓	✓
PRKAR2A	✓	✓
PRKAR2B	✓	✓
TBP	✓	✓