PrimePCR™ Probe Assay: CASP4, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: CASP4, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: CASP4, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0031810
Assay Design:   Intron-spanning
Chromosome Location:   11:104820402-104821721question
Amplicon Length:   143
Splice Variants Targeted:   ENST00000444739 ENST00000393150 ENST00000355546

Gene Information

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein as well as caspase 1 precursor. When overexpressed this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq Jul 2008]

Gene Symbol:   CASP4
Gene Name:   caspase 4, apoptosis-related cysteine peptidase
Aliases:   ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
RefSeq:   NC_000011.9 NT_033899.8
Ensembl:   ENSG00000196954
Entrez:   837
Chromosome Mapping:   11q22.2-q22.3

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