PrimePCR™ Probe Assay: ABCC8, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: ABCC8, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: ABCC8, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0049175
Assay Design:   exonic
Chromosome Location:   11:17474692-17474813question
Amplicon Length:   92
Splice Variants Targeted:   ENST00000389817 ENST00000302539

Gene Information

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1 MDR/TAP MRP ALD OABP GCN20 White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however the transcript variants have not been fully described. [provided by RefSeq Jul 2008]

Gene Symbol:   ABCC8
Gene Name:   ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Aliases:   ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, TNDM2
RefSeq:   NC_000011.9 NG_008867.1 NG_012446.1 NT_009237.18
Ensembl:   ENSG00000006071
Entrez:   6833
Chromosome Mapping:   11p15.1

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