Cerebral small vessel diseases

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Disease State Panels

PrimePCR disease state panels were designed by referencing the National Library of Medicine database. Disease state panels allow for the thorough investigation of differentially expressed genes within a specified pathology.

Gene targets for each disease state were ranked and compared according to the following criteria:

Frequency of gene expression changes in biomarker studies
Popularity in overall medical research
Popularity in current medical research

The resulting gene scores were used to design real-time PCR panels. For diseases with a large number of gene targets, multiple tiered plates are available. Tier 1 plates represent the highest ranked targets with subsequent tiers containing the lower ranked or less well characterized targets.

Target Details

Click on a target from the pathway image to view related information.

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GeneCode	Cerebral small vessel diseases H96	Cerebral small vessel diseases H384
AAK1	✓	✓
ACADVL	✗	✓
AKAP9	✓	✓
APAF1	✗	✓
ATP5E	✓	✓
ATP5J2	✓	✓
ATP5O	✓	✓
ATP6V1C1	✗	✓
ATRX	✓	✓
BLK	✓	✓
BNC2	✗	✓
BRD8	✗	✓
BTG1	✓	✓
C10orf2	✗	✓
CALM1	✓	✓
CALM2	✓	✓
CALM3	✓	✓
CCDC78	✓	✓
CCL2	✓	✓
CCL3	✓	✓
CCL4	✓	✓
CHD9	✓	✓
CHST2	✓	✓
CIITA	✗	✓
COPS5	✓	✓
COX5B	✓	✓
COX7C	✓	✓
CPT2	✓	✓
CREBBP	✓	✓
CYBA	✓	✓
DICER1	✓	✓
DPYSL2	✓	✓
EEF1D	✓	✓
EIF4E2	✗	✓
ERBB2	✓	✓
FAM179A	✗	✓
FOXO1	✓	✓
FUS	✓	✓
FXR1	✓	✓
GALNT14	✗	✓
GAPDH	✓	✓
GLA	✓	✓
GRHL2	✓	✓
GSPT1	✗	✓
HIST1H2BD	✓	✓
HNRNPA2B1	✓	✓
HNRNPA3	✓	✓
HNRNPD	✓	✓
HPRT1	✓	✓
HPSE	✓	✓
HSD17B10	✓	✓
IFRD1	✓	✓
IGF1	✓	✓
IL8	✓	✓
IVNS1ABP	✗	✓
JARID2	✗	✓
JMJD6	✗	✓
KDM4B	✓	✓
KDM5B	✓	✓
LGR6	✓	✓
LPIN1	✓	✓
LSM3	✓	✓
LSM7	✗	✓
MAP3K5	✓	✓
MAP4K4	✓	✓
MARCKS	✓	✓
MCTS1	✗	✓
MTHFD1	✓	✓
N4BP2	✗	✓
NCOA1	✓	✓
NDUFA4	✓	✓
NDUFB8	✓	✓
NEDD8	✓	✓
NIPBL	✓	✓
NUDC	✓	✓
PAX5	✓	✓
PBXIP1	✗	✓
PHACTR1	✓	✓
PKM2	✓	✓
PML	✗	✓
POLR2F	✗	✓
POU2AF1	✗	✓
PPP3CA	✓	✓
PRKD2	✓	✓
PROCR	✗	✓
PRSS23	✓	✓
PSMB4	✓	✓
PTTG1	✓	✓
QKI	✓	✓
RBM6	✓	✓
ROCK1	✓	✓
RPS10	✗	✓
RPS14	✓	✓
RPS6KA5	✓	✓
RPS6KB2	✓	✓
RUNX3	✓	✓
S100A12	✗	✓
S100A4	✓	✓
SERTAD2	✗	✓
SESN2	✗	✓
SET	✗	✓
SLC16A1	✓	✓
SOCS1	✓	✓
SOD2	✓	✓
SPON2	✓	✓
SRPK1	✓	✓
STAT1	✓	✓
STX7	✗	✓
SUB1	✓	✓
SUMO1	✓	✓
TBC1D12	✓	✓
TBP	✓	✓
TCF7L2	✓	✓
TFAM	✓	✓
TGFBR3	✓	✓
TP53BP1	✓	✓
TUBE1	✗	✓
UGCG	✗	✓
UQCRC2	✓	✓
VAPA	✓	✓
WBP4	✗	✓
ZCCHC6	✗	✓
ZNF827	✓	✓

GeneCode	Cerebral small vessel diseases M96	Cerebral small vessel diseases M384
Aak1	✓	✓
Acadvl	✗	✓
Akap9	✓	✓
Apaf1	✓	✓
Atp5e	✓	✓
Atp5j2	✓	✓
Atp5k	✗	✓
Atp5o	✓	✓
Atp6v1c1	✓	✓
Atrx	✓	✓
Blk	✓	✓
Bnc2	✗	✓
Brd8	✗	✓
Btg1	✓	✓
Calm1	✓	✓
Ccdc78	✓	✓
Ccl12	✓	✓
Ccl4	✓	✓
Chd9	✓	✓
Chst2	✓	✓
Ciita	✗	✓
Cops5	✓	✓
Cox5b	✓	✓
Cox7c	✓	✓
Cpt2	✓	✓
Crebbp	✓	✓
Cyba	✓	✓
Dicer1	✓	✓
Dpysl2	✓	✓
Eef1d	✓	✓
Eif4e2	✗	✓
Erbb2	✓	✓
Fam179a	✗	✓
Foxo1	✓	✓
Fus	✓	✓
Fxr1	✓	✓
Galnt14	✗	✓
Gapdh	✓	✓
Gla	✓	✓
Gpr56	✗	✓
Grhl2	✓	✓
Gspt1	✗	✓
Hnrnpa2b1	✓	✓
Hnrnpa3	✓	✓
Hnrnpd	✓	✓
Hprt	✓	✓
Hpse	✓	✓
Hsd17b10	✓	✓
Ifrd1	✓	✓
Igf1	✓	✓
Ivns1abp	✗	✓
Jarid2	✗	✓
Jmjd6	✗	✓
Kdm4b	✓	✓
Kdm5b	✓	✓
Lgr6	✓	✓
Lpin1	✓	✓
Lsm3	✓	✓
Lsm7	✗	✓
Map3k5	✓	✓
Map4k4	✓	✓
Marcks	✓	✓
Mcts1	✗	✓
Mthfd1	✓	✓
N4bp2	✓	✓
Ncoa1	✓	✓
Ndufa4	✓	✓
Ndufb8	✓	✓
Nedd8	✓	✓
Nipbl	✓	✓
Nudc	✓	✓
Pax5	✓	✓
Pbxip1	✓	✓
Peo1	✗	✓
Phactr1	✓	✓
Pkm	✓	✓
Pml	✗	✓
Polr2f	✗	✓
Pou2af1	✗	✓
Ppp3ca	✓	✓
Prkd2	✓	✓
Procr	✗	✓
Prss23	✓	✓
Psmb4	✓	✓
Pspc1	✗	✓
Pttg1	✓	✓
Qk	✓	✓
Rasef	✗	✓
Rbm6	✓	✓
Rock1	✓	✓
Rps10	✗	✓
Rps14	✓	✓
Rps6ka5	✓	✓
Rps6kb2	✓	✓
Runx3	✓	✓
S100a4	✓	✓
Sertad2	✓	✓
Sesn2	✗	✓
Set	✗	✓
Slc16a1	✓	✓
Socs1	✓	✓
Sod2	✓	✓
Spon2	✓	✓
Srpk1	✓	✓
Stat1	✓	✓
Stk17b	✗	✓
Stx7	✗	✓
Sub1	✓	✓
Sumo1	✓	✓
Tbc1d12	✓	✓
Tbp	✓	✓
Tbx21	✗	✓
Tcf7l2	✓	✓
Tfam	✓	✓
Tgfbr3	✓	✓
Trp53bp1	✓	✓
Tube1	✗	✓
Ugcg	✗	✓
Uqcrc2	✓	✓
Vapa	✓	✓
Wbp4	✗	✓
Zcchc6	✗	✓
Zfp827	✓	✓

GeneCode	Cerebral Small Vessel Diseases R96	Cerebral Small Vessel Diseases R384
Akap9	✓	✓
Atp5e	✓	✓
Atp5j2	✗	✓
Atp5o	✓	✓
Atrx	✗	✓
Ccl12	✓	✓
Ccl4	✓	✓
Cox5b	✓	✓
Cox7c	✗	✓
Crebbp	✓	✓
Cyba	✗	✓
Dicer1	✓	✓
Dpysl2	✓	✓
Foxo1	✓	✓
Gapdh	✓	✓
Gla	✗	✓
Grhl2	✗	✓
Hist1h2bd	✓	✓
Hnrnpa2b1	✓	✓
Hnrpd	✓	✓
Hprt1	✓	✓
Hpse	✓	✓
Hsd17b10	✓	✓
Ifrd1	✗	✓
Igf1	✓	✓
Kdm4b	✓	✓
Kdm5b	✓	✓
Lpin1	✗	✓
Lsm3	✗	✓
Map3k5	✓	✓
Map4k4	✗	✓
Marcks	✓	✓
Mthfd1	✓	✓
Ncoa1	✓	✓
Phactr1	✓	✓
Pkm	✓	✓
Ppp3ca	✓	✓
Prkd2	✓	✓
Psmb4	✓	✓
Pttg1	✓	✓
Qk	✓	✓
Rock1	✓	✓
Runx3	✓	✓
S100a4	✓	✓
Slc16a1	✗	✓
Socs1	✓	✓
Sod2	✓	✓
Spon2	✗	✓
Srpk1	✓	✓
Stat1	✓	✓
SUB1	✗	✓
Sumo1	✓	✓
Tbp	✓	✓
Tcf7l2	✓	✓
Tgfbr3	✓	✓
Trp53bp1	✗	✓
Uqcrc2	✗	✓
Vapa	✗	✓
Zfp827	✓	✓